✦ LIBER ✦

Investigation of retention and chiral recognition mechanism using quantitative structure-enantioselectivity retention relationship in high performance liquid chromatography

✍ Scribed by Chen Hui; Lu Xian-Yu; Gao Ru-Yu; Huang Jun-Min; Yang Hua-Zheng; Wang Qun-Sun

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 258 KB
Volume: 18
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.20000180211

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✦ Synopsis

Abstract

The enantiomers of a series of fourteen O‐ethyl O‐(substituted) phenyl N‐isopropyl‐phosphoroamidothioates have been separated by high performance liquid chromatography (HPLC) on the Pirkle‐type chiral stationary phase. Seven molecular descriptors were calculated and four significant descriptors were chosen to correlate against the experimental ln__k'__ values in order to form the quantitative structure‐enantioselectivity retention relationships (QSERRs). Through the QSERRs, the retention and enantioselectivity mechanism were examined.

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