Investigation of reperfusion injury and ischemic preconditioning in microsurgery

✍ Scribed by Wei Zhong Wang

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 111 KB
• Volume: 29
• Category: Article
• ISSN: 0738-1085
• DOI: 10.1002/micr.20587

✦ Synopsis

Abstract

Ischemia/reperfusion (I/R) is inevitable in many vascular and musculoskeletal traumas, diseases, free tissue transfers, and during time‐consuming reconstructive surgeries in the extremities. Salvage of a prolonged ischemic extremity or flap still remains a challenge for the microvascular surgeon. One of the common complications after microsurgery is I/R‐induced tissue death or I/R injury. Twenty years after the discovery, ischemic preconditioning has emerged as a powerful method for attenuating I/R injury in a variety of organs or tissues. However, its therapeutic expectations still need to be fulfilled. In this article, the author reviews some important experimental evidences of I/R injury and preconditioning‐induced protection in the fields relevant to microsurgery. © 2008 Wiley‐Liss, Inc. Microsurgery, 2009.