Investigation of Ligand-Receptor Systems by High-Resolution Solid-State NMR: Recent Progress and Perspectives

✍ Scribed by Sorin Luca; Henrike Heise; Adam Lange; Marc Baldus

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 363 KB
• Volume: 338
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200400991

✦ Synopsis

Abstract

Solid‐state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non‐crystalline and insoluble environment. We discuss the latest methodolo gical progress to construct 3D molecular structures from solid‐state NMR data obtained under magic‐angle‐spinning conditions. As shown for the neurotensin/NTS‐1 system, these methods can be readily applied to the investigation of ligand‐binding to G‐protein coupled receptors.