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Investigation of Genetic Alterations Associated with Development and Adverse Outcome in Patients with Astrocytic Tumor

✍ Scribed by A.M. Cianciulli; E. Morace; A.M. Coletta; E. Occhipinti; G.M. Gandolfo; G. Leonardo; C.M. Carapella


Book ID
110235235
Publisher
Springer US
Year
2000
Tongue
English
Weight
67 KB
Volume
48
Category
Article
ISSN
0167-594X

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Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome. We used CGH to study the genetic alterations that occur in primary astrocytomas, including 14 glioblastomas (GBM), 12 anaplastic astrocytomas (AA), and 7

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## Abstract ## BACKGROUND In oligodendroglial tumors, allelic losses on chromosome arms 1p and 19q are not only diagnostic molecular markers but also statistically significant predictors of both chemosensitivity and longer recurrence‐free survival. In the current study, the authors attempted to an