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Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882

โœ Scribed by Dingemanse, Jasper; Nicolas, Laurent B.; van Bortel, Luc


Book ID
125342596
Publisher
Springer
Year
2014
Tongue
English
Weight
245 KB
Volume
70
Category
Article
ISSN
0031-6970

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## Purpose: Act-178882, a direct renin inhibitor, was used as a model compound in an elaborate drug-drug interaction study with atorvastatin and simvastatin to explore complex cyp3a4 inductive and inhibitory properties. ## Methods: Thirty-two healthy male subjects received single doses of 20 mg a

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