## Purpose: Act-178882, a direct renin inhibitor, was used as a model compound in an elaborate drug-drug interaction study with atorvastatin and simvastatin to explore complex cyp3a4 inductive and inhibitory properties. ## Methods: Thirty-two healthy male subjects received single doses of 20 mg a
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Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882
โ Scribed by Dingemanse, Jasper; Nicolas, Laurent B.; van Bortel, Luc
- Book ID
- 125342596
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 245 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0031-6970
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