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Investigation of a BDK-1 free-piston expander-compressor

โœ Scribed by A. M. Arkharov; V. B. Gridin; A. Z. Mirkin


Publisher
Springer
Year
1973
Tongue
English
Weight
296 KB
Volume
9
Category
Article
ISSN
0009-2355

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We report the large-scale synthesis of 1,3-cyclooctanedione in five steps with 29% yield. This molecule is a synthetic precursor to difluorinated cyclooctyne, which participates in a bioorthogonal copper-free click reaction with azides. The final step demonstrates the first successful application of