Investigation into the possible influence of chlorinated amphetamine derivatives on 5-hydroxytryptamine synthesis in man
✍ Scribed by H. M. Praag; J. Korf; F. Woudenberg
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 468 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
In test animals, 4-chloro-N-methylamphetamine (CMA) and 4-ehloroamphetamine (4-CA) cause a decrease in the cerebral 5-HT and 5-HIAA concentrations; they exert no appreciable influence on eatecholamine concentrations. In man, these compounds have a therapeutic effect on depression. In terms of antidepressant effect, they resemble not so much the nonehlorinated amphetamine derivatives as the true antidepressants.
This paper considers the question whether the influence of CMA and 4-CA on the 5-HT metabolism is based on inhibition of 5-tIT synthesis. No arguments to support this hypothesis were found; findings obtained did support the postulate that these compounds are 5-HT depletors.
In conclusion, a possible explanation of the antidepressant effect of chlorinated amphetamine derivatives is offered.