✦ LIBER ✦

Investigating the stereochemistry of binding to HIV-1 protease with inhibitors containing isomers of 4-amino-3-hydroxy-5-phenylpentanoic acid

✍ Scribed by B. Raju; Milind S. Deshpande

Book ID: 117055485
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 226 KB
Volume: 180
Category: Article
ISSN: 0006-291X
DOI: 10.1016/s0006-291x(05)81274-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Inhibitors of Human Immunodeficiency Vir

Inhibitors of Human Immunodeficiency Virus Type 1 Protease Containing 2-Aminobenzyl-Substituted 4-Amino-3-hydroxy-5-phenylpentanoic Acid: Synthesis, Activity, and Oral Bioavailability

✍ Lehr, Philipp; Billich, Andreas; Charpiot, Brigitte; Ettmayer, Peter; Scholz, Di 📂 Article 📅 1996 🏛 American Chemical Society 🌐 English ⚖ 233 KB

Stereoselective synthesis of N-Boc-O-ben

Stereoselective synthesis of N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid, the hydroxyethylene isosteric moiety of potent HIV-1 protease inhibitor

✍ Tk Chakraborty; Kiran Kumar Gangakhedkar 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 152 KB

N-Boc-O-benzyl-(4S,5S)-5-amino-4-hydroxy-6-phenylhexanoic acid is synthesized in a highly stereoselective way involving, as a key step, regioselective opening of carbohydrate-based aziridine ring.

Nonpeptidic HIV Protease Inhibitors: 4-H

Nonpeptidic HIV Protease Inhibitors: 4-Hydroxy-pyran-2-one Inhibitors with Functional Tethers to P1Phenyl Ring to Reach S3Pocket of the Enzyme

✍ J.V.N. Vara Prasad; Peter J. Tummino; Donna Ferguson; James Saunders; Steve Vand 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 624 KB

Altered sensitivity of an R5X4 HIV-1 str

Altered sensitivity of an R5X4 HIV-1 strain 89.6 to coreceptor inhibitors by a single amino acid substitution in the V3 region of gp120

✍ Yosuke Maeda; Keisuke Yusa; Shinji Harada 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 471 KB

Structures of the Ligand-Binding Core of

Structures of the Ligand-Binding Core of iGluR2 in Complex with the Agonists ( R )- and ( S )-2-Amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic Acid Explain Their Unusual Equipotency ⊥

✍ Beich-Frandsen, Mads; Pickering, Darryl S.; Mirza, Osman; Johansen, Tommy N.; Gr 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 466 KB