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Investigating the binding specificity of U1A-RNA by computational mutagenesis

✍ Scribed by Carolina M Reyes; Peter A Kollman


Book ID
115629835
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
209 KB
Volume
295
Category
Article
ISSN
0022-2836

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Anti-U1A monoclonal antibodies recognize
✍ Carol S. Lutz; Micah T. McClain; John B. Harley; Judith A. James πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 229 KB

## Abstract The U1A (or nRNP A) protein is known to play a critical role in eukaryotic pre‐mRNA splicing and polyadenylation. Previous studies revealed that several mouse monoclonal antibodies (MAbs) recognized U1A as part of the U1snRNP, while MAb 12E12 was unique in that it recognized an epitope