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Inversion of enantioselectivity for the hydrogenation of ethyl pyruvate in the gas-phase over Pt/SiO2 modified with derivatives of hydroquinidine

✍ Scribed by Nicholas F. Dummer; Robert Jenkins; Xiabao Li; Salem M. Bawaked; Paul McMorn; Andrew Burrows; Christopher J. Kiely; Richard P.K. Wells; David J. Willock; Graham J. Hutchings


Book ID
113686057
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
340 KB
Volume
243
Category
Article
ISSN
0021-9517

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New chiral modifiers in enantioselective
✍ A Solladié-Cavallo; C Marsol; F Garin 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 64 KB

New chiral and enantiopure erythro and threo 1,2-amino-alcohols 4a and 4b have been shown to accelerate the heterogeneous catalytic hydrogenation of ethyl pyruvate as much as cinchonidine does (with 77-100% conversion within 2 h). A diastereo dependence of the enantioselectivity is clearly observed