Inversion-associated translocations in acute myelomonocytic leukemia with eosinophilia

✍ Scribed by Roland Berger; Josette Derré; Maryvonne Le Coniat; Josette Hébert; P. Serge Romana; Philippe Jonveaux

• Book ID: 102846801
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 799 KB
• Volume: 12
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870120110

✦ Synopsis

Cytogenetic studies of three acute myelomonocytic leukemias with bone marrow eosinophilia (M4EO) revealed chromosome I 6 inversion associated with additional abnormalities. The inverted chromosome I6 was involved in two patients. Fluorescence in situ hybridization (FISH) experiments with a YAC probe detecting inv( 16) showed that the translocation breakpoints involving chromosome I 6 did not implicate the inversion breakpoints. FISH can thus distinguish between true variant translocations and translocations with other breakpoints on chromosome I6 in M4EO.