Inverse effects of ethidium bromide on superoxide dismutase and lactate dehydrogenase ofArtemia salina embryos
✍ Scribed by Bremner, Theodore A. ;Edwards, Kimberly A.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 391 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Development of Artemia salina embryos in the presence of ethidium bromide, an inhibitor of mitochondrial transcription, results in a dose dependent increase in the specific activity of lactate dehydrogenase, and a concomitant decrease in the specific activity of a cyanide-resistant superoxide dismutase. The inhibition of mitochondrial function by ethidium bromide appears to exert opposite effects on the nuclear cistrons encoding lactate dehydrogenase and superoxide dismutase, and suggests that a common mitochondrial signal may exert diametric effects on nuclear cistrons whose products are characteristic of alternate states of respiration.