Inverse Detection and Heteronuclear Editing in 1H–15N Correlation and 1H–1H Double-Quantum NMR Spectroscopy in the Solid State under Fast MAS

✍ Scribed by Ingo Schnell; Benedikt Langer; Serge H.M. Söntjens; Marcel H.P. van Genderen; Rint P. Sijbesma; Hans Wolfgang Spiess

• Publisher: Elsevier Science
• Year: 2001
• Tongue: English
• Weight: 371 KB
• Volume: 150
• Category: Article
• ISSN: 1090-7807
• DOI: 10.1006/jmre.2001.2312

✦ Synopsis

Signal enhancement in heteronuclear correlation spectra as well as signal selection in 1 H experiments can be achieved through inverse, i.e., 1 H, detection in the solid state under fast MAS conditions. Using recoupled polarization transfer (REPT), a heteronuclear 1 H-15 N single-quantum correlation (HSQC) experiment is presented whose symmetrical design allows the frequency dimensions to be easily interchanged. By observing the 15 N dimension indirectly and detecting on 1 H, the sensitivity is experimentally found to be increased by factors between 5 and 10 relative to conventional 15 N detection. In addition, the inverse 1 H-15 N REPT-HSQC scheme can be readily used as a filter for the 1 H signal. As an example, we present the combination of such a heteronuclear filter with a subsequent 1 H-1 H DQ experiment, yielding two-dimensional 15 N-edited 1 H-1 H DQ MAS spectra. In this way, specific selection or suppression of 1 H resonances is possible in solid-state MAS experiments, by use of which the resolution can be improved and information can be unravelled in 1 H spectra.