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Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer

โœ Scribed by Tin-Lap Lee; Wai K Leung; James Y.W Lau; Joanna H.M Tong; Enders K.W Ng; Francis K.L Chan; S.C.Sydney Chung; Joseph J.Y Sung; Ka-Fai To

Book ID
117466953
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
416 KB
Volume
168
Category
Article
ISSN
0304-3835

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## Dear Sir, The RAS proteins participate in the RAS-RAF-MEK-ERK-MAPKinase pathway, which mediates cellular responses to growth signals. 1 There are 3 RAF genes, each encoding cytoplasmic serine/threonine kinases that are regulated by binding to RAS. 1,2 We have recently reported that BRAF is soma