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Invariant chain modulates HLA class II protein recycling and peptide presentation in nonprofessional antigen presenting cells

โœ Scribed by Azizul Haque; Laela M. Hajiaghamohseni; Ping Li; Katherine Toomy; Janice S. Blum


Book ID
113527076
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
486 KB
Volume
249
Category
Article
ISSN
0008-8749

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MHC class II-associated invariant chain
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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e