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Invariant chain as a tool to load antigenic peptides on MHC class I

✍ Scribed by Sébastien Wälchli; Ole Landsverk; Lars-Egil Fallang; Johanna Olweus; Oddmund Bakke; Tone Gregers

Book ID
113805722
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
57 KB
Volume
51
Category
Article
ISSN
0161-5890

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MHC class II-associated invariant chain
MHC class II-associated invariant chain peptide replacement by T cell epitopes: engineered invariant chain as a vehicle for directed and enhanced MHC class II antigen processing and presentation
✍ Georg Malcherek; Christoph Wirblich; Nicholas Willcox; Hans-Georg Rammensee; Joh 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB

Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e