Invagination and infolding of podocytes in glomerular basement membrane in the cases of primary membranous nephropathy
โ Scribed by Yukinari Masuda; Akiko Mii; Akira Shimizu; Emiko Fujita; Kaoru Aki; Kahori Ishikawa; Masamichi Ishizaki; Shigeru Sato; Naoaki Hayama; Yasuhiko Iino; Yasuo Katayama; Yuh Fukuda
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 1004 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1342-1751
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In membranous nephropathy (MN), the glomerular basement membrane (GBM) is thickened due to accumulation of GBM material between and around the subepithelial immune deposits. Alterations in the GBM components in relation to subepithelial deposits and GBM thickening are not clearly defined. The GBM di
Immunogold densities for the 'classical' and 'novel' chains of type IV collagen, laminin, and fibronectin are increased in the spikes in human membranous nephropathy (MN). To investigate the molecular mechanisms which underlie these changes in glomerular basement membrane (GBM) components, 1(IV) col