Introduction to Proteins : Structure, Function, and Motion, Second Edition

✍ Scribed by Ben-Tal, Nir; Kessel, Amit

• Publisher: CRC Press
• Year: 2018
• Tongue: English
• Leaves: 989
• Series: Chapman and Hall/CRC mathematical & computational biology series
• Edition: Second edition
• Category: Library

✦ Synopsis

"Introduction to Proteins shows how proteins can be analyzed in multiple ways. It refers to the roles of proteins and enzymes in diverse contexts and everyday applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. This edition includes a brand-new chapter on enzymatic catalysis and biochemistry, an in-depth discussion of G-protein-coupled receptors (GPCRs), and a wider-scale description of methods for studying proteins."--Provided by publisher. Read more...

Abstract: "Introduction to Proteins shows how proteins can be analyzed in multiple ways. It refers to the roles of proteins and enzymes in diverse contexts and everyday applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. This edition includes a brand-new chapter on enzymatic catalysis and biochemistry, an in-depth discussion of G-protein-coupled receptors (GPCRs), and a wider-scale description of methods for studying proteins."--Provided by publisher

✦ Table of Contents

Content: Cover
Half Title
Abstact
Title
Copyrights
Contents
List Of Figures
List Of Tables
List Of Boxes
Preface
Changes In Second Edition
Acknowledgments
Authors
Physical Quantities Andconstants
List Of Acronyms
Chapter 1. Introduction
1.1 Importance Of Proteins In Living Organisms
1.1.1 Life, Proteins And Mysterious Forces
1.1.2 Molecular Organization Of Living Organisms
1.1.3 Proteins Have Numerous Biological Roles
1.1.3.1 Catalysis Of Metabolic Processes
1.1.3.2 Energy Transfer
1.1.3.3 Gene Expression
1.1.3.4 Transport Of Solutes Across Biological Membranes. 1.1.3.5 Cellular Communication1.1.3.6 Molecular Recognition
1.1.3.7 Defense
1.1.3.8 Forming Intracellular And Extracellular Structures
1.1.3.9 Cell- And Tissue-specific Functions
1.1.4 Physiological And Evolutionary Importance Of Proteins
1.1.5 Medical, Industrial, And Social Importance Of Proteins
1.1.5.1 Proteins As Drug Targets
1.1.5.2 Proteins As Toxin Targets
1.1.5.3 Industrial Applications Of Proteins
1.2 Structural Complexity And Its Effect On Protein Function
1.3 Noncovalent Interactions Between Atoms In Biomolecules
1.3.1 Electrostatic Interactions
1.3.1.1 Introduction. 1.3.1.2 Basic Principles1.3.1.3 Hydrogen Bonds
1.3.1.4 Other Types Of Electrostatic Interactions
1.3.2 Van Der Waals Interactions
1.3.3 Nonpolar Interactions And Hydrophobic Effect
1.3.4 Conclusions
1.4 Summary
1.5 Organization Of Book
Exercises
References
Chapter 2. Protein Structure
2.1 Introduction
2.1.1 Hierarchy In Protein Structure
2.1.2 Coenzymes And Prosthetic Groups
2.2 Primary Structure
2.2.1 Amino Acids And Their Properties
2.2.1.1 Amino Acid Structure
2.2.1.2 Configurations Of Amino Acids
2.2.1.3 Side Chain Properties
2.2.1.4 Amino Acid Derivates In Proteins. 2.2.2 Peptide Bond2.3 Secondary Structure
2.3.1 .-helix
2.3.1.1 Geometry
2.3.1.2 Intramolecular Interactions
2.3.1.3 Amphipathic .-helices
2.3.2 Non-.-helices
2.3.2.1 310-helix
2.3.2.2 .-helix
2.3.2.3 Type Ii Polyproline Helix (ppii
2.3.3 . Conformation
2.3.4 Why Helices And Sheets
2.3.5 Reverse Turns
2.3.5.1 .-turn
2.3.5.2 Loops
2.3.6 Secondary Structure Preferences Of Amino Acids
2.3.6.1 .-helix
2.3.6.2 . Conformation
2.4 Tertiary Structure
2.4.1 Basic Properties Of Tertiary Structure
2.4.1.1 Structural Properties Required For Complex Function. 2.4.1.2 Core Versus Surface2.4.1.3 Stabilizing Forces
2.4.2 Architecture Of Proteins
2.4.2.1 Simple Folding Motifs
2.4.2.2 Complex Folds
2.4.2.3 Domains
2.4.2.4 Protein Classification
2.4.2.5 Knotted Proteins
2.4.3 Evolutionary Conservation Of Structure And Function In Proteins
2.4.3.1 Interests Of Individual Versus Those Of Species
2.4.3.2 Structure Conservation: Evolutionary Mechanisms
2.4.3.3 Evolution Of Function
2.4.4 Water Molecules Inside Proteins
2.5 Quaternary Structure
2.5.1 Introduction
2.5.2 Characteristics
2.5.2.1 Dimensions And Complexity
2.5.2.2 Symmetry.

✦ Subjects

Biochemistry.;Bioinformatics.;Biophysics.;CHEMLIBnetBASE.;PHYSICSnetBASE.;SCI-TECHnetBASE.;COMPUTERSCIENCEnetBASE.;CHEMISTRYnetBASE.;INFORMATIONSCIENCEnetBASE.;STMnetBASE.;Proteins.;Proteins -- Structure-activity relationships.;Physical biochemistry.;SCIENCE / Life Sciences / Biochemistry.