Introduction to Computational Biology: An Evolutionary Approach

✍ Scribed by Bernhard Haubold, Thomas Wiehe

• Publisher: Birkhäuser Basel
• Year: 2007
• Tongue: German
• Leaves: 343
• Edition: 1st Corrected ed. 2006. Corr. 3rd printing 2007
• Category: Library

✦ Synopsis

Written with the advanced undergraduate in mind, this book introduces into the field of Bioinformatics. The authors explain the computational and conceptional background to the analysis of large-scale sequence data. Many of the corresponding analysis methods are rooted in evolutionary thinking, which serves as a common thread throughout the book. The focus is on methods of comparative genomics and subjects covered include: alignments, gene finding, phylogeny, and the analysis of single nucleotide polymorphisms (SNPs). The volume contains exercises, questions & answers to selected problems.

✦ Table of Contents

Cover_978-3-7643-6700-8......Page 1
front-matter......Page 2
CopyRight......Page 3
Dedication......Page 4
Preface......Page 5
Contents......Page 6
1 Introduction......Page 12
Part I: Sequences in Space......Page 20
2 Optimal Pairwise Alignment......Page 22
3 Biological Sequences and the Exact String MatchingProblem......Page 58
4 Fast Alignment: Genome Comparison and DatabaseSearching......Page 80
5 Multiple Sequence Alignment......Page 106
6 Sequence Profiles and Hidden Markov Models......Page 116
7 Gene Prediction......Page 132
Part II: Sequences in Time......Page 156
8 Phylogeny......Page 158
9 Sequence Variation and Molecular Evolution......Page 184
10 Genes in Populations: Forward in Time......Page 202
11 Genes in Populations: Backward in Time......Page 232
12 Testing Evolutionary Hypotheses......Page 260
BackMatter......Page 274