Introduction of tritium into organic compounds by isotope exchange reactions

✍ Scribed by N. F. Myasoedov

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 469 KB
• Volume: 33
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580330505

✦ Synopsis

Abstract

Various isotope exchange reactions for the introduction of tritium into a range of organic compounds have been investigated. The influence of the catalyst, solvent and reaction conditions on the yield and specific activities of a number of steroids, phytohormones and sugars are reported. Heterogeneous hydrogen isotope exchange with gaseous tritium has also been used to label a number of nonpolar compounds. Similarly the potential of solid state hydrogen isotope exchange has been explored. The reaction mechanism is discussed as well as the influence of the reaction conditions on the specific activity and the label distribution.