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Introduction of the Human proα 1(I) Collagen Gene into proα 1(I)-deficient Mov-13 Mouse Cells Leads to Formation of Functional Mouse-Human Hybrid Type I Collagen

✍ Scribed by Angelika Schnieke, Marie Dziadek, John Bateman, Tom Mascara, Klaus Harbers, Richard Gelinas and Rudolf Jaenisch

Book ID
123633779
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
952 KB
Volume
84
Category
Article
ISSN
0027-8424

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## Abstract The __oim__ mouse is a model of human Osteogenesis Imperfecta (OI) that has deficient synthesis of proα2(I) chains. Cells isolated from __oim__ mice synthesize α1(I) collagen homotrimers that accumulate in tissues. To explore the feasibility of gene therapy for OI, a murine proα2(I) cDN