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Introducing a new recruitment design for genetic association studies in opioid dependence

✍ Scribed by P. Franke; B. Wendel; M. Knapp; S.G. Schwab; W. Maier; D.B. Wildenauer; M.R. Hoehe


Book ID
119568368
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
121 KB
Volume
17
Category
Article
ISSN
0924-9338

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## Abstract We present a new method, the δ‐centralization (DC) method, to correct for population stratification (PS) in case‐control association studies. DC works well even when there is a lot of confounding due to PS. The latter causes overdispersion in the usual chi‐square statistics which then h