Intrinsic stability and functional prope
โ
A. J. GALE; K.-P. RADTKE; M. A. CUNNINGHAM; D. CHAMBERLAIN; J.-L. PELLEQUER; J.
๐
Article
๐
2006
๐
John Wiley and Sons
๐
English
โ 350 KB
Background: The utility of purified coagulation factor (F)VIII for treatment of hemophilia A is limited in part by its instability following activation by thrombin, which is caused by spontaneous dissociation of the A2 domain from the activated FVIII (FVIIIa) heterotrimer. To prevent this A2 domain