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Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants

โœ Scribed by A. J. GALE; K.-P. RADTKE; M. A. CUNNINGHAM; D. CHAMBERLAIN; J.-L. PELLEQUER; J. H. GRIFFIN


Book ID
109151544
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
350 KB
Volume
4
Category
Article
ISSN
1538-7933

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Intrinsic stability and functional prope
โœ A. J. GALE; K.-P. RADTKE; M. A. CUNNINGHAM; D. CHAMBERLAIN; J.-L. PELLEQUER; J. ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 350 KB

Background: The utility of purified coagulation factor (F)VIII for treatment of hemophilia A is limited in part by its instability following activation by thrombin, which is caused by spontaneous dissociation of the A2 domain from the activated FVIII (FVIIIa) heterotrimer. To prevent this A2 domain