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Intrinsic specificity of Ca2+–protein binding sites

✍ Scribed by Alex Reiter; Hong Zhao; Jeanette Adams

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
533 KB
Volume
28
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

The gas‐phase chemistry of anionic [M + Cat^2+^ – 3H]^−^ complexes between Ca^2+^‐specific peptides and the alkaline earth metal ions Mg^2+^, Ca^2+^ and Ba^2+^ is reported. The metal ion complexes were studied using fast atom bombardment, collision‐induced decomposition (CID) and molecular mechanical calculations. The CID reactions and molecular mechanical calculations revealed that the Ca^2+^–peptide complexes are bound differently to the Mg^2+^– and Ba^2+^–peptide complexes and that the intrinsic (gas‐phase) chemistry is reflected by known aqueousphase chemistry.

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