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Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT1A receptors

✍ Scribed by Anna Agnieszka Strzelczyk; Malgorzata Jarończyk; Zdzisław Chilmonczyk; Aleksander Paweł Mazurek; Ewa Chojnacka-Wójcik; Ingebrigt Sylte

Book ID: 113487133
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 393 KB
Volume: 67
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2004.02.026

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## Abstract The affinity of a ligand for a receptor is usually expressed in terms of the dissociation constant (__K__~__i__~) of the drug‐receptor complex, conveniently measured by the inhibition of radioligand binding. However, a ligand can be an antagonist, a partial agonist, or a full agonist, a