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Intravesical chemotherapy: Combination with dimethyl sulfoxide does not enhance cytotoxicity in vitro

✍ Scribed by Walker, L. ;Walker, M. C. ;Parris, C. N. ;Masters, J. R. W.

Publisher: Springer
Year: 1988
Tongue: English
Weight: 296 KB
Volume: 16
Category: Article
ISSN: 0300-5623
DOI: 10.1007/bf00263647

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✦ Synopsis

There is evidence that dimethyl sulfoxide (DMSO) can increase the anticancer activity of chemotherapeutic drugs. As DMSO is instilled into the bladder for interstitial cystitis, it could be readily adopted in clinical practice if it was found to enhance the effectiveness of the drugs used for intravesical chemotherapy. The purpose of this study was to investigate, using a human bladder cancer cell line, the hypothesis that DMSO enhances the activity of these agents. However, the addition of 4% DMSO to the four drugs most frequently used for intravesical chemotherapy (adriamycin, epodyl, mitomycin-c, thiotepa) did not increase tumour cell kill in vitro.

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Intravesical chemotherapy: Combination with tween 80 increases cytotoxicity in vitro

✍ Parris, C.N. ;Masters, J.R.W. ;Walker, M.C. ;Newman, B. ;Riddle, P. ;English, P. 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 280 KB

Tween 80 was shown to enhance significantly the cytotoxic activities of the four drugs (adriamycin, epodyl, mitomycin-c, thiotepa) most frequently administered intravesically to treat superficial bladder cancer. The colony forming ability of a human bladder cancer cell line, RT112, was measured foll