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Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)

✍ Scribed by Paola Dal Cin; Bradley J. Quade; David M. Neskey; Michael S. Kleinman; Stanislawa Weremowicz; Cynthia C. Morton

Book ID: 102218221
Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 49 KB
Volume: 36
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.10159

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✦ Synopsis

Abstract

Intravenous leiomyomatosis (IVL) is a rare smooth‐muscle proliferation that is of special interest because of its quasi‐malignant behavior. Our finding of a specific chromosomal aberration, a der(14)t(12;14)(q15;q24), in a second case of IVL suggests that it may be characteristic of IVL. We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15‐qter and/or loss of 14q24‐qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation. © 2003 Wiley‐Liss, Inc.

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