𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intravenous immunoglobulin therapy: New aspects and outlook

✍ Scribed by Imbach, P. ;Barandun, S. ;Baumgartner, Ch. ;Gaedicke, G. ;Hirt, A. ;Wagner, H. P.


Publisher
Springer-Verlag
Year
1984
Weight
220 KB
Volume
48
Category
Article
ISSN
1432-0584

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✦ Synopsis


Experiences gathered while exploring the usefulness of intravenous immunoglobulin for children with idiopathic (immune) thrombocytopenic purpura (ITP) are reviewed in view of further investigations characterizing the effects of IgG i.v. in other immune diseases without detectable antibody deficiency. The most pertinent factors to be considered are i) the heterogeneity of an immune disease investigated; ii) the criteria used to evaluate the effects of the IgG therapy; iii) the IgG preparations used and i.v. dose-fractionation. Controlled, prospective clinical trials will be required to further explore the practical usefulness of IgG i.v.


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Seven patients with thrombocytopenia and systemic lupus erythematosus were treated with intravenous (IV) doses of human immunoglobulin to assess clinical response and to examine the mechanism of action of IV immunoglobulin in these patients. Five of 7 patients had a >50% increase in their platelet c