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Intravenous CDP870, a PEGylated Fab′ fragment of a humanized antitumour necrosis factor antibody, in patients with moderate-to-severe Crohn's disease: an exploratory study

✍ Scribed by T. A. Winter; J. Wright; S. Ghosh; J. Jahnsen; A. Innes; P. Round


Book ID
108603895
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
140 KB
Volume
20
Category
Article
ISSN
0269-2813

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Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub