๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Intravenous administration of paclitaxel in Sprague-Dawley rats: what is a safe dose?

โœ Scribed by Stacy S. Shord; Joseph R. Camp


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
84 KB
Volume
27
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Pharmacokinetic study of all-trans-retin
โœ Hai-Shu Lin; Arun B. Barua; James A. Olson; Kerwin Siew Yang Low; Sui Yung Chan; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

All-trans-retinoyl-b-D-glucuronide (RAG) is an endogenous active metabolite of all-trans-retinoic acid (ATRA). In the present study, the pharmacokinetics of RAG was examined after the administration of a single intravenous does (5, 10, or 15 mmol/kg) and of multiple daily intravenous doses (5 mmol/k

A safety study of oral xanthohumol admin
โœ Ragna Hussong; Norbert Frank; Jutta Knauft; Carina Ittrich; Robert Owen; Hans Be ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 148 KB ๐Ÿ‘ 1 views

Xanthohumol (XN) is a prenylated chalcone, which has been shown to possess a broad range of potential cancer preventive and additional biological activities. In the present study, we have determined the subchronic 4-wk toxicity of XN and monitored its influence on fertility and development of offspr

Kinetic study of a 2-hydroxypropyl-ฮฒ-cyc
โœ Hai-Shu Lin; Sui Yung Chan; Kerwin Siew Yang Low; Mei Leng Shoon; Paul C. Ho ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 191 KB ๐Ÿ‘ 1 views

all-trans-Retinoic acid (ATRA, vitamin A acid, or tretinoin) is a potent chemotherapeutic agent for the treatment of acute promyelocytic leukemia (APL). Its poor aqueous solubility not only affects its oral absorption but also prevents it from forming an aqueous parenteral formulation. Recently, we

PHARMACOKINETICS OF ACEBUTOLOL ENANTIOME
โœ S. ABOLFAZL MOSTAFAVI; ROBERT T. FOSTER ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 147 KB ๐Ÿ‘ 2 views

Acebutolol (AC) is a chiral b-adrenergic blocking drug, possessing intrinsic sympathomimetic activity (ISA), and is useful clinically as the racemate in treating hypertension. Utilizing a stereospeciยฎc high-performance liquid chromatographic (HPLC) assay, the enantiomeric disposition of AC and its m

A phase I study of sequential administra
โœ Caio M. S. Rocha Lima; Carlo V. Catapano; Daniel Pacheco; Carol A. Sherman; Greg ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 114 KB ๐Ÿ‘ 1 views

## Abstract ## BACKGROUND Based on preclinical findings and on the clinical antitumor efficacy of sequential paclitaxel/topotecan and topotecan/etoposide, the authors sought to define the maximum tolerated doses (MTDs) and doseโ€limiting toxicities (DLTs) associated with a sequential combination of

Acute administration of Ginkgo biloba ex
โœ E-Jian Lee; Hung-Yi Chen; Tian-Shung Wu; Tsung-Ying Chen; Issam A. Ayoub; Kennet ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 294 KB

We examined the neuroprotective action of a standardized extract of Ginkgo biloba leaves (EGb 761) in permanent and transient middle cerebral artery (MCA) occlusion models in Sprague-Dawley rats. Forty-four animals were given either EGb 761 (50-200 mg/kg) or vehicle intraperitoneally, 1 hr before pe