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Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure

โœ Scribed by Johanos, Andrew M.


Book ID
123412571
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
139 KB
Volume
10
Category
Article
ISSN
0736-4679

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๐Ÿ“œ SIMILAR VOLUMES


Improved outcome of paracetamol-induced
โœ Harrison, P.M.; Keays, R.; Bray, G.P.; Alexander, G.J.M.; Williams, R. ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› The Lancet ๐ŸŒ English โš– 301 KB

The influence of acetylcysteine, administered at presentation to hospital, on the subsequent clinical course of 100 patients who developed paracetamol-induced fulminant hepatic failure was analysed retrospectively. Mortality was 37% in patients who received acetylcysteine 10-36 h after the overdose,

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Background. When administered early after an overdose of acetaminophen, intravenous acetylcysteine prevents hepatic necrosis by replenishing reduced stores of glutathione. How acetylcysteine improves the survival of patients with established liver damage induced by acetaminophen, however, is unknown