Intravascular ultrasound analysis of nonstented adjacent segments in diffuse in-stent restenosis treated with radiation therapy with a rhenium-188–filled balloon
✍ Scribed by Myeong-Ki Hong; Seong-Wook Park; Dae-Hyuk Moon; Seung-Jun Oh; Cheol Whan Lee; Young-Hak Kim; Jae-Whan Lee; Jong-Min Song; Duk-Hyun Kang; Jae-Kwan Song; Jae-Joong Kim; Seung-Jung Park
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 74 KB
- Volume
- 58
- Category
- Article
- ISSN
- 1522-1946
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✦ Synopsis
Abstract
The effects of β‐radiation therapy on nonstented adjacent segments in in‐stent restenosis have not been sufficiently evaluated. β‐radiation therapy for in‐stent restenosis was performed with a ^188^Re‐MAG~3~–filled balloon. We evaluated the effects of β‐radiation therapy on nonstented adjacent segments in in‐stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients who received radiation therapy vs. 9 control patients. The changes (Δ = follow‐up − postintervention) of the external elastic membrane (EEM), the lumen, and other IVUS variables were compared between the segments that received radiation therapy and the control segments. The significant differences between the two groups were as follows: Δ EEM area was 0.3 mm^2^ in the radiation vs. −1.0 mm^2^ in the control (P = 0.005) and Δ lumen area was 0.2 mm^2^ vs. −1.3 mm^2^, respectively (P < 0.001). In conclusion, compared with the changes of vessel shrinkage in the control group, significant vessel enlargement occurred in the nonstented adjacent segments that received radiation therapy. Cathet Cardiovasc Intervent 2003;58:428–433. © 2003 Wiley‐Liss, Inc.