Intravascular behavior of perflubron emulsions

✍ Scribed by D.H. Klein; R.C. Jones; P.E. Keipert; G.A. Luena; S. Otto; J.G. Weers

• Book ID: 103966680
• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 523 KB
• Volume: 84
• Category: Article
• ISSN: 0927-7757
• DOI: 10.1016/0927-7757(93)02703-h

✦ Synopsis

Perflubron emulsion particles are removed from the circulation of test animals by the organs of the reticuloendothelial system (RES). Initial removal is rapid and results in a loading of the RES. Subsequent removal is first order in perflubron concentration, but the rate constant is inversely related to perflubron dose. At longer times, the perflubron which initially went to the RES is solubilized in blood lipids.

For particles stabilized with egg yolk phospholipid (EYP), the first-order perfluorocarbon elimination rate constant is directly proportional to particle size and is not dependent on the identity of the emulsified perfluorocarbon.

The rate constant can be changed by addition of surface modifiers to the EYP. In rats, most changes speed elimination.

In rabbits, the rate constants are much smaller than in rats, but the size dependence is still present. Changing the particle surface also affects the elimination rates in rabbits. The results of surface changes are highly species dependent, and the intravascular behavior of perflubron emulsions in rabbits is very different from that in rats, dogs and swine.