Intratumoral heterogeneity of DNA content in lung adenocarcinoma
β Scribed by Hiroyuki Miura; Osamu Taira; Shunsuke Hiraguri; Masaru Hagiwara; Harubumi Kato
- Publisher
- Springer Japan
- Year
- 1998
- Tongue
- Japanese
- Weight
- 719 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1863-6705
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π SIMILAR VOLUMES
## BACKGROUND. A multiple sampling study was performed on 124 specimens of renal cell carcinomas to analyze the consistency and reliability of DNA measurements. The authors investigated intratumoral DNA heterogeneity and its role as a adverse prognostic factor for disease progression. ## METHODS
## Abstract We retrospectively examined by flow cytometry the DNA ploidy pattern in tissue blocks from 25 primary colon adenocarcinomas and their lymph node and liver metastases. Intratumoral heterogeneity was present in 22% of primary tumors and 21% of metastatic liver deposits. Intertumoral heter