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Intratumoral budding as a potential parameter of tumor progression in mismatch repair–proficient and mismatch repair–deficient colorectal cancer patients

✍ Scribed by Alessandro Lugli; Tatjana Vlajnic; Olivier Giger; Eva Karamitopoulou; Efstratios S. Patsouris; George Peros; Luigi M. Terracciano; Inti Zlobec


Book ID
116534965
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
849 KB
Volume
42
Category
Article
ISSN
1532-8392

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Regulatory T cells (T reg ) inhibit the generation of host-versus-tumor immunity via suppression of tumor-specific effector T-cell responses and development of immune tolerance to neoplastic cells. The transcription factor forkhead box P3 (FOXP3) is an intracellular key molecule for T reg developmen