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Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy

✍ Scribed by Pierre Lebon; Jean Badoual; Gérard Ponsot; Françoise Goutières; Françoise Hémeury-Cukier; Jean Aicardi

Book ID
118930577
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
378 KB
Volume
84
Category
Article
ISSN
0022-510X

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## Abstract Increased ammonia is a major pathogenic factor in hepatic encephalopathy (HE), a neurologic syndrome associated with glutamatergic dysfunction. Previous studies have shown that in rat cerebral cortical slices or a glia‐derived cell line, acute treatment with ammonia in vitro and in vivo