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Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids

✍ Scribed by X.-Y. Hua; P. Chen; M. Marsala; T.L. Yaksh

Book ID: 117492732
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 914 KB
Volume: 89
Category: Article
ISSN: 0306-4522
DOI: 10.1016/s0306-4522(98)00488-6

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Following brain injury, astrocytes express receptors for cytokines and neuropeptides and secrete several regulatory mediators that have a well established role in inflammation, immunity, and tissue development or repair. To elucidate the role of substance P (SP), a neurotransmitter peptide of the ta