𝔖 Bobbio Scriptorium
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Intrathecal immune activation in three patients with progressive myoclonic ataxia

✍ Scribed by A. Salmaggi; F. Carella; C. Ciano; S. Binelli; P. Giovannini; E. Palazzini; Dr. F. Girotti

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
321 KB
Volume
10
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Three patients displaying a clinical picture of progressively evolving multifocal action myoclonus and cerebellar ataxia showed a marked intrathecal immune activation, which was persistent over a 2‐ to 5‐year time span in the two serially investigated patients. A thorough search for metabolic, toxic, infectious, or degenerative causes of myoclonus was unsuccessful. The presence of intrathecal immune activation in at least a subgroup of patients with the clinical features of progressive myoclonic ataxia suggests the possibility of immune‐mediated damage within the central nervous system in this condition.

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