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Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

✍ Scribed by Calias, Pericles; Banks, William A.; Begley, David; Scarpa, Maurizio; Dickson, Patricia

Book ID
124134912
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
354 KB
Volume
144
Category
Article
ISSN
0163-7258

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## Abstract Peptides and regulatory proteins hold great promise as therapeutic agents for the central nervous system (CNS). However, the blood–brain barrier (BBB) is a major obstacle to the delivery of these potential therapeutics to their site of action. We concentrate here on the vascular BBB, wh