✦ LIBER ✦

Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia

✍ Scribed by Vito Annese; Mario Basciani; Osvaldo Borrelli; Gioacchino Leandro; Pasquale Simone; Angelo Andriulli

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 76 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2

No coin nor oath required. For personal study only.

✦ Synopsis

We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24 ± 15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.

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