Intrapleural instillation of urokinase in the treatment of loculated pleural effusions in children
β Scribed by Gustavo Stringel; Alan R. Hartman
- Book ID
- 115993784
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 231 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-3468
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π SIMILAR VOLUMES
Intrapleural administration of fibrinolytic agents such as urokinase (UK) has been advocated as an alternative method to manage complicated pleural effusion (CPE). Despite the increasing number of empyemas successfully treated with UK in adults, the experience in children is limited to a few cases.
A group of 21 patients with malignant pleural effusions were treated with the instillation of 40 mg mitoxantrone intrapleurally, after complete fluid drainage. There was a 100% complete response rate with no toxic effects (0%). The mean survival of the patients was 57.1 weeks.