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Intraperitoneal infusion of doxorubicin in the treatment of gynecologic carcinomas

✍ Scribed by Roboz, John ;Jacobs, Allan J. ;Holland, James F. ;Deppe, Gunter ;Cohen, Carmel J.

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 368 KB
Volume: 9
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950090307

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Intraperitoneally administered doxorubicin yields high local concentrations that are expected to deliver higher doses to clinically important peritoneal and lymphatic metastatic sites. Two infusions of 20 mg and 30 mg in a patient with residual microscopic intraperitoneal ovarian cancer eradicated her disease. Quantification of serum doxorubicin by HPLC revealed significant levels of the drug and its major metabolite lasting 72 hours. A 50‐mg infusion induced complete remission in endometrial carcinoma; the patient died in 6 months without evidence of abdominal tumor. Complications due to subcutaneous infiltration of doxorubicin and possible systemic effects of sustained high levels of the drug need further investigation to enable the full exploitation of this modality.

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