Intraperitoneal and intraamygdala N6-cyclohexyladenosine suppress hippocampal kindled seizures in rats

✍ Scribed by Javad Mirnajafi-Zadeh; Yaghoub Fathollahi; Mohammad Hossein Pourgholami

• Book ID: 114005656
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 400 KB
• Volume: 858
• Category: Article
• ISSN: 0006-8993
• DOI: 10.1016/s0006-8993(99)02425-7

✦ Synopsis

Effects of intraperitoneal and intraamygdala N(6)-cyclohexyladenosine (CHA), a selective adenosine A(1) receptor agonist, and 1,3-dimethyl-8-cyclopentylxanthine (CPT), a selective adenosine A(1) receptor antagonist, were examined in fully hippocampal kindled rats. Intraperitoneal administration of CHA (0. 25, 0.5 and 1 mg/kg) decreased hippocampal secondary afterdischarge duration (SAD) and amygdala afterdischarge duration (ADD). Only the 1 mg/kg dose induced a significant increase in latency to stage 4. Intraperitoneal administration of CPT (0.25, 0.5 and 1 mg/kg) induced a significant increase in stage 5 duration, hippocampal SAD and ADD. Pretreatment of animals with CPT (1 mg/kg), antagonized effects of CHA on seizure parameters. Intraamygdala microinfusion (1 microl over 2 min) of CHA (5 nM-1 mM) significantly reduced hippocampal SAD and amygdala ADD. These effects were antagonized by intraamygdala CPT (1 microM). Results obtained suggest that in hippocampal kindled rats, amygdala may be regarded as a relay point for AD propagation specially in recruit activity of the hippocampus.