Intraosseous infusion of prostaglandin E2 prevents disuse-induced bone loss in the tibia
✍ Scribed by R. D. Welch; R. B. Ashman; K. J. Baker; R. H. Browne
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 932 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0736-0266
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✦ Synopsis
Abstract
We investigated whether intraosseous injection of prostaglandin E~2~ would preserve tibial bone mass in the skeletally unloaded limb of a large animal model. Skeletal unloading of one rear limb was produced by unilateral Achilles tenectomy in the goat. Prostaglandin E~2~ was injected at 0.5 or 1.0 mg (1 ml of volume) twice daily, beginning on day 7 and continuing for 10 days, through an implant that had been surgically placed in the proximal tibial metaphysis. Thirty‐five days after surgery, the tibiae were harvested for measurement of static and dynamic bone parameters and mechanical characteristics using transmission ultrasound. Prostaglandin E~2~ produced a dose‐dependent increase in the formation of woven new bone at all bone envelopes. The 1.0 mg dosage prevented and partially reversed the effects of skeletal unloading and added new bone (p < 0.05) compared with the unloaded tibiae. Because prostaglandin E~2~ increased both bone formation and resorption and the new bone produced was primarily woven bone, the material properties of the tibiae infused with prostaglandin E~2~ did not increase significantly during the study compared with the unloaded and weight‐bearing tibiae.