Intraoperative radiotherapy (IORT) is an innovative treatment approach that has been tested in several Phase 1-11 studies and small Phase 111 trials in patients with resectable and unresectable pancreatic cancer. The technical approach and dose guidelines for adjacent normal tissues have been establ
Intraoperative radiotherapy for pancreatic carcinoma: Experimental and clinical studies
β Scribed by Timothy J. Kinsella; William F. Sindelar
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 639 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
Intraoperative radiotherapy (IORT) is an innovative treatment approach that has been tested in several Phase 1-11 studies and small Phase 111 trials in patients with resectable and unresectable pancreatic cancer. The technical approach and dose guidelines for adjacent normal tissues have been established in a series of experiments using a large animal (canine) model. This article reviews the experimental and clinical studies of IORT in cancer of the pancreas.
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A detailed retrospective analysis of the efficacy of intraoperative radiotherapy (IOR) in advanced carcinoma of the pancreas is presented. During a 10-year period from 1973 through 1982, 70 patients with advanced carcinoma of the pancreas were treated by multimodal methods, separate or combined ther