Intraoperative irradiation: A pilot study combining external beam photons with “boost” dose intraoperative electrons

✍ Scribed by Leonard L. Gunderson; William U. Shipley; Herman D. Suit; Edward R. Epp; George Nardi; William Wood; Alfred Cohen; James Nelson; George Battit; Peter J. Biggs; Anthony Russell; Agnes Rockett; Dianna Clark

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 746 KB
• Volume: 49
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19820601)49:11<2259::aid-cncr2820491110>3.0.co;2-q

✦ Synopsis

lntraoperntive ''boost" dose electron beam therapy given in combination with 4500-5000 rad (45-50 Gray) external beam irradiation has been demonstrated as a practical therapeutic modality at the MGH. This procedure has been employed thus far in 58 patients; the results in the initial 36 are analyzed in detail in this paper. Thirty-four of the 36 patients had locally advanced lesions-unresectable, recurrent, or residual disease. Results achieved to date are in full agreement with our expectations: high radiation doses have been delivered to the primary intra-abdominal and pelvic tumors, excluding the sensitive structures from irradiation. This has been accomplished by a truly multidisciplinary effort comprising surgery, anesthesiology, OR nursing, administration, engineers, physicists, therapy technologists, and radiation therapists. Although follow-up is not yet sufficient to judge ultimate efficacy, acute and chronic severe morbidity is low and local control is good. There is justified enthusiasm for continuing the procedure.