Intraoperative evaluation of bony margins with frozen-section analysis and trephine drill extraction technique: A preliminary study
✍ Scribed by Andreas Wysluch; Ingo Stricker; Frank Hölzle; Klaus-Dietrich Wolff; Peter Maurer
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 218 KB
- Volume
- 32
- Category
- Article
- ISSN
- 1043-3074
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✦ Synopsis
Abstract
Background
The aim of this study was to examine the use of trephine drill specimens from mandible bony margins subjected to standard histologic fresh‐frozen processing for intraoperative documentation of malignant bony infiltration in oral cancer.
Methods
Eighty‐four drill specimens were extracted from bony mandibular resection margins of 20 patients with oral cancer. Histologic results of decalcification and of intraoperative frozen‐section analysis were compared.
Results
Sixty‐eight (81%) of 84 specimens showed no tumor infiltration, whereas 16 (19%) were positive in frozen section analysis. Four specimens (4.8%) were evaluated as free of tumor invasion, but showed erosion of the bone by the tumor after decalcification. One specimen (2.4%) was positive, but no invasion could be found with standard decalcification. Overall, there was 94% (79) consistency between the 2 techniques, with a sensitivity of 79% and specificity of 98%.
Conclusion
This technique promises to be suitable for intraoperative detection of malignant bone infiltration. © 2010 Wiley Periodicals, Inc. Head Neck, 2010