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Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

✍ Scribed by Oliver Wirths; Gerd Multhaup; Christian Czech; Véronique Blanchard; Saliha Moussaoui; Günter Tremp; Laurent Pradier; Konrad Beyreuther; Thomas A Bayer

Book ID
117471808
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
581 KB
Volume
306
Category
Article
ISSN
0304-3940

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## Abstract A recent report showed that the accumulation of α‐synuclein (α‐syn) was detected in the brains of one‐third of Alzheimer's disease and Down syndrome patients. However, the relationship between amyloid‐β protein (Aβ) and α‐syn remains unclear. We analyzed the relation between the mutatio