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Intranasal scopolamine hydrobromide: pH affects absorption


Book ID
120867824
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2000
Weight
139 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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The purpose of this study was to investigate whether changes in the pH of the gastrointestinal tract can directly affect P-glycoprotein (P-gp) function. The effect of changes in extracellular pH on P-gp functionality was examined by testing colchicine (a nonionizable P-gp substrate) in bidirectional