The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS), posing a significant challenge to drug development efforts to treat neurological and psychiatric diseases and disorders. Intranasal delivery is a noninvasive and conve
Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
โ Scribed by Dhuria, Shyeilla V. (author);Hanson, Leah R. (author);Frey, William H. (author)
- Publisher
- John Wiley and Sons Inc.
- Year
- 2010
- Tongue
- English
- Weight
- 325 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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The blood-brain barrier (BBB) limits the distribution of systemically administered therapeutics to the central nervous system (CNS). Intranasal delivery is a noninvasive method that targets drugs to the brain and spinal cord along olfactory and trigeminal neural pathways, bypassing the BBB and minim
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